VIPR1 This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 Belongs to the G-protein coupled receptor 2 family. In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR

Chromosomal Location of mouse Ortholog: 9 F4|9 72.5 cM

Cellular Component: membrane; plasma membrane; receptor complex

Molecular Function: G protein-coupled peptide receptor activity; G protein-coupled receptor activity; peptide hormone binding; transmembrane signaling receptor activity; vasoactive intestinal polypeptide receptor activity

Biological Process: adenylate cyclase-modulating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; signal transduction

Reference #: P97751 (UniProtKB)

Alt. Names/Synonyms: AV071699; PACAP type II receptor; PACAP-R-2; PACAP-R2; Pituitary adenylate cyclase-activating polypeptide type II receptor; vasoactive intestinal peptide receptor 1; Vasoactive intestinal polypeptide receptor 1; VIP receptor subtype 1; VIP-R-1; VIP-R1; Vipr1; VPAC1

Gene Symbols: Vipr1

Molecular weight: 52,096 Da

Basal Isoelectric point: 8.08 Predict pI for various phosphorylation states

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VIPR1

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