VIPR1 This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 Belongs to the G-protein coupled receptor 2 family. In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 9 F4|9 72.5 cM
Cellular Component:  integral component of membrane; membrane; plasma membrane; receptor complex
Molecular Function:  G protein-coupled peptide receptor activity; G protein-coupled receptor activity; peptide hormone binding; transmembrane signaling receptor activity; vasoactive intestinal polypeptide receptor activity
Biological Process:  cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; signal transduction
Reference #:  P97751 (UniProtKB)
Alt. Names/Synonyms: AV071699; PACAP type II receptor; PACAP-R-2; PACAP-R2; Pituitary adenylate cyclase-activating polypeptide type II receptor; vasoactive intestinal peptide receptor 1; Vasoactive intestinal polypeptide receptor 1; VIP receptor subtype 1; VIP-R-1; VIP-R1; Vipr1; VPAC1
Gene Symbols: Vipr1
Molecular weight: 52,096 Da
Basal Isoelectric point: 8.08  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene