VIPR1 This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 Belongs to the G-protein coupled receptor 2 family. In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3p22.1
Cellular Component:  integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function:  peptide hormone binding; protein binding; vasoactive intestinal polypeptide receptor activity
Biological Process:  cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; positive regulation of cell proliferation
Reference #:  P32241 (UniProtKB)
Alt. Names/Synonyms: FLJ41949; HVR1; II; PACAP type II receptor; PACAP-R-2; PACAP-R2; pituitary adenylate cyclase activating polypeptide receptor, type II; Pituitary adenylate cyclase-activating polypeptide type II receptor; RDC1; type 1 vasoactive intestinal peptide receptor; V1RG; VAPC1; vasoactive intestinal peptide receptor 1; Vasoactive intestinal polypeptide receptor 1; VIP and PACAP receptor 1; VIP receptor, type I; VIP-R-1; VIPR; VIPR1; VIRG; VPAC1; VPAC1 receptor; VPAC1R; VPCAP1R
Gene Symbols: VIPR1
Molecular weight: 51,547 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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