VAMP4 Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. Belongs to the synaptobrevin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 1q24.3
Cellular Component:  cell surface; clathrin-coated vesicle membrane; endosome; Golgi apparatus; Golgi membrane; integral component of synaptic vesicle membrane; lysosome; plasma membrane; trans-Golgi network membrane; transport vesicle
Molecular Function:  protein binding
Biological Process:  Golgi ribbon formation; membrane organization; microtubule cytoskeleton organization; regulation of synaptic vesicle endocytosis; SNARE complex assembly; synaptic vesicle to endosome fusion
Reference #:  O75379 (UniProtKB)
Alt. Names/Synonyms: VAMP-4; VAMP24; VAMP4; VAMP4/TAF3 fusion; vesicle associated membrane protein 4; Vesicle-associated membrane protein 4
Gene Symbols: VAMP4
Molecular weight: 16,397 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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