CDH5 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Endothelial tissues and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q21
Cellular Component:  cell junction; cell surface; cell-cell adherens junction; cell-cell junction; external side of plasma membrane; integral component of membrane; membrane; plasma membrane
Molecular Function:  beta-catenin binding; ion channel binding; protein binding; protein phosphatase binding; signaling receptor binding; vascular endothelial growth factor receptor 2 binding
Biological Process:  adherens junction organization; blood vessel maturation; cell-cell junction assembly; negative regulation of cell proliferation; negative regulation of inflammatory response; positive regulation of angiogenesis; positive regulation of establishment of endothelial barrier; regulation of establishment of cell polarity; transforming growth factor beta receptor signaling pathway
Reference #:  P33151 (UniProtKB)
Alt. Names/Synonyms: 7B4; 7B4 antigen; CADH5; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144; cd144 antigen; CDH5; endothelial-specific cadherin; FLJ17376; Vascular endothelial cadherin; VE-cadherin
Gene Symbols: CDH5
Molecular weight: 87,528 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene