RIPK3 Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group
Chromosomal Location of human Ortholog: 14q12
Cellular Component:  cytoplasm; cytosol; nucleus; protein-containing complex
Molecular Function:  ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transcription coactivator activity
Biological Process:  activation of protein kinase activity; amyloid fibril formation; apoptotic signaling pathway; cellular response to hydrogen peroxide; defense response to virus; execution phase of necroptosis; I-kappaB kinase/NF-kappaB signaling; lymph node development; necroptotic process; necroptotic signaling pathway; NIK/NF-kappaB signaling; positive regulation of DNA-templated transcription; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of ligase activity; positive regulation of necroptotic process; positive regulation of NF-kappaB transcription factor activity; positive regulation of oxidoreductase activity; positive regulation of phosphatase activity; positive regulation of reactive oxygen species metabolic process; programmed necrotic cell death; protein autophosphorylation; protein modification process; reactive oxygen species metabolic process; regulation of activated T cell proliferation; regulation of activation-induced cell death of T cells; regulation of adaptive immune response; regulation of apoptotic process; regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; regulation of T cell mediated cytotoxicity; regulation of type II interferon production; signal transduction; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development
Reference #:  Q9Y572 (UniProtKB)
Alt. Names/Synonyms: receptor interacting protein 3; receptor interacting serine/threonine kinase 3; Receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; RIP3; RIPK3
Gene Symbols: RIPK3
Molecular weight: 56,887 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB