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RIPK3
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group |
| Chromosomal Location of human Ortholog: 14q12 |
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Cellular Component:
cytoplasm; cytosol; nucleus; protein-containing complex
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Molecular Function:
ATP binding; identical protein binding; NF-kappaB-inducing kinase activity; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; transcription coactivator activity
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Biological Process:
activation of protein kinase activity; amyloid fibril formation; apoptotic signaling pathway; cellular response to hydrogen peroxide; defense response to virus; execution phase of necroptosis; I-kappaB kinase/NF-kappaB signaling; lymph node development; necroptotic process; necroptotic signaling pathway; NIK/NF-kappaB signaling; positive regulation of DNA-templated transcription; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of ligase activity; positive regulation of necroptotic process; positive regulation of NF-kappaB transcription factor activity; positive regulation of oxidoreductase activity; positive regulation of phosphatase activity; positive regulation of reactive oxygen species metabolic process; programmed necrotic cell death; protein autophosphorylation; protein modification process; reactive oxygen species metabolic process; regulation of activated T cell proliferation; regulation of activation-induced cell death of T cells; regulation of adaptive immune response; regulation of apoptotic process; regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; regulation of T cell mediated cytotoxicity; regulation of type II interferon production; signal transduction; spleen development; T cell differentiation in thymus; T cell homeostasis; thymus development
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Reference #:
Q9Y572
(UniProtKB)
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Alt. Names/Synonyms: receptor interacting protein 3; receptor interacting serine/threonine kinase 3; Receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; RIP3; RIPK3
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Gene Symbols: RIPK3
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Molecular weight:
56,887 Da
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Basal Isoelectric point:
6.08
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Death Receptor Signaling
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Inhibition of Apoptosis
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NF-kB Signaling
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Regulation of P38 MAPKs
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SAPK/JNK Signaling Cascades
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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