CDH5
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Endothelial tissues and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis |
Chromosomal Location of mouse Ortholog: 8 D3|8 53.04 cM |
Cellular Component:
adherens junction; anchoring junction; bicellular tight junction; catenin complex; cell junction; cell periphery; cell surface; cell-cell junction; external side of plasma membrane; membrane; nuclear membrane; nucleoplasm; plasma membrane
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Molecular Function:
beta-catenin binding; BMP receptor binding; cadherin binding; calcium ion binding; fibrinogen binding; metal ion binding; protein binding; protein phosphatase binding; protein tyrosine kinase binding; signaling receptor binding; transmembrane transporter binding; vascular endothelial growth factor receptor 2 binding
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Biological Process:
adherens junction organization; bicellular tight junction assembly; blood vessel endothelial cell migration; blood vessel maturation; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; cell morphogenesis; cell-cell adhesion; cell-cell adhesion mediated by cadherin; cell-cell junction assembly; homophilic cell adhesion via plasma membrane adhesion molecules; intracellular calcium ion homeostasis; multicellular organism development; negative regulation of cell population proliferation; negative regulation of endothelial cell apoptotic process; negative regulation of inflammatory response; negative regulation of microtubule polymerization; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cell migration; positive regulation of establishment of endothelial barrier; positive regulation of gene expression; positive regulation of protein dephosphorylation; positive regulation of protein-containing complex assembly; protein localization to bicellular tight junction; regulation of establishment of cell polarity; regulation of protein phosphorylation; regulation of vascular permeability; transforming growth factor beta receptor signaling pathway; vasculature development
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Reference #:
P55284
(UniProtKB)
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Alt. Names/Synonyms: 7B4; 7B4/cadherin-5; AA408225; CADH5; cadherin 5; Cadherin-5; Cd144; Cdh5; Vascular endothelial cadherin; VE-C; VE-Cad; VE-cadherin; Vec; VEcad; VECD
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Gene Symbols: Cdh5
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Molecular weight:
87,903 Da
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Basal Isoelectric point:
5.15
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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