DATF1 Putative transcription factor, weakly pro-apoptotic when overexpressed. Tumor suppressor. Required for early embryonic stem cell development. Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of mouse Ortholog: 2|2 H4
Cellular Component:  cytoplasm; cytoskeleton; nucleoplasm; nucleus
Molecular Function:  metal ion binding
Biological Process:  apoptotic process; apoptotic signaling pathway; DNA-templated transcription
Reference #:  Q8C9B9 (UniProtKB)
Alt. Names/Synonyms: 6720461J16Rik; C130092D22Rik; C530043I07; D130048F08Rik; Datf; DATF-1; Datf1; death inducer-obliterator 1; death inducer-obliterator-2; death inducer-obliterator-3; Death-associated transcription factor 1; Death-inducer obliterator 1; dido; Dido1; Dido2; Dido3; DIO; DIO-1; Dio1; mKIAA0333; OTTMUSP00000017582; OTTMUSP00000017583; OTTMUSP00000017584; OTTMUSP00000017585; OTTMUSP00000017586
Gene Symbols: Dido1
Molecular weight: 247,176 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene