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PAR3-beta
Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. Belongs to the PAR3 family. Highly expressed in kidney, lung and skeletal muscle. Expressed at intermediate levels in brain, heart, placenta, liver and pancreas. Isoform 1 is predominant, while isoform 2 and isoform 3 are expressed at lower levels. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 2q33.3 |
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Cellular Component:
adherens junction; apical junction complex; apical plasma membrane; bicellular tight junction; cell cortex; cell junction; endomembrane system; protein-containing complex
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Molecular Function:
phosphatidylinositol binding; protein binding
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Biological Process:
cell adhesion; cell cycle; cell division; establishment of cell polarity; establishment of centrosome localization; establishment or maintenance of epithelial cell apical/basal polarity; microtubule cytoskeleton organization; protein localization
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Reference #:
Q8TEW8
(UniProtKB)
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Alt. Names/Synonyms: ALS2CR19; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 19 protein; MGC16131; par-3 family cell polarity regulator beta; par-3 partitioning defective 3 homolog B; par-3 partitioning defective 3 homolog B (C. elegans); PAR3-beta; PAR3-L protein; PAR3B; PAR3beta; PAR3L; Par3Lb; PAR3LC; PARD3B; Partitioning defective 3 homolog B; Partitioning defective 3-like protein; partitioning-defective 3-beta; partitioning-defective 3-like
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Gene Symbols: PARD3B
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Molecular weight:
132,494 Da
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Basal Isoelectric point:
8.54
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Microtubule Dynamics
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