DGKA Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. Belongs to the eukaryotic diacylglycerol kinase family. Lymphocytes and oligodendroglial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q11
Cellular Component:  cytosol; plasma membrane
Molecular Function:  ATP binding; calcium ion binding; diacylglycerol kinase activity; kinase activity; NAD+ kinase activity; phospholipid binding
Biological Process:  diacylglycerol metabolic process; glycerolipid metabolic process; intracellular signal transduction; lipid phosphorylation; phosphatidic acid biosynthetic process; protein kinase C-activating G protein-coupled receptor signaling pathway
Reference #:  P51556 (UniProtKB)
Alt. Names/Synonyms: 80 kDa diacylglycerol kinase; DAG kinase alpha; Dagk; Dagk1; DGK-alpha; Dgka; Diacylglycerol kinase alpha; diacylglycerol kinase, alpha; Diglyceride kinase alpha
Gene Symbols: Dgka
Molecular weight: 82,199 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene