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DGKA
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. Belongs to the eukaryotic diacylglycerol kinase family. Lymphocytes and oligodendroglial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 7q11 |
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Cellular Component:
cytosol; plasma membrane
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Molecular Function:
ATP binding; ATP-dependent diacylglycerol kinase activity; calcium ion binding; kinase activity; lipid binding; phospholipid binding
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Biological Process:
diacylglycerol metabolic process; glycerolipid metabolic process; intracellular signal transduction; lipid phosphorylation; phosphatidic acid biosynthetic process; protein kinase C-activating G protein-coupled receptor signaling pathway
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Reference #:
P51556
(UniProtKB)
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Alt. Names/Synonyms: 80 kDa diacylglycerol kinase; DAG kinase alpha; Dagk; Dagk1; DGK-alpha; Dgka; Diacylglycerol kinase alpha; diacylglycerol kinase, alpha; Diglyceride kinase alpha
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Gene Symbols: Dgka
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Molecular weight:
82,199 Da
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Basal Isoelectric point:
6
Predict pI for various phosphorylation states
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