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DGKA
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. Belongs to the eukaryotic diacylglycerol kinase family. Lymphocytes and oligodendroglial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 12q13.2 |
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Cellular Component:
cytosol; plasma membrane
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Molecular Function:
ATP binding; ATP-dependent diacylglycerol kinase activity; calcium ion binding; kinase activity; lipid binding; phospholipid binding
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Biological Process:
diacylglycerol metabolic process; glycerolipid metabolic process; intracellular signal transduction; lipid phosphorylation; phosphatidic acid biosynthetic process; platelet activation; protein kinase C-activating G protein-coupled receptor signaling pathway
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Reference #:
P23743
(UniProtKB)
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Alt. Names/Synonyms: 80 kDa diacylglycerol kinase; DAG kinase alpha; DAGK; DAGK1; DGK-alpha; DGKA; Diacylglycerol kinase alpha; diacylglycerol kinase, alpha 80kDa; Diglyceride kinase alpha; MGC12821; MGC42356
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Gene Symbols: DGKA
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Molecular weight:
82,630 Da
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Basal Isoelectric point:
6.28
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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