DGKA Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. Belongs to the eukaryotic diacylglycerol kinase family. Lymphocytes and oligodendroglial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q13.2
Cellular Component:  cytosol; plasma membrane
Molecular Function:  ATP binding; calcium ion binding; diacylglycerol kinase activity; kinase activity; NAD+ kinase activity; phospholipid binding
Biological Process:  diacylglycerol metabolic process; glycerolipid metabolic process; lipid phosphorylation; phosphatidic acid biosynthetic process; platelet activation; protein kinase C-activating G protein-coupled receptor signaling pathway
Reference #:  P23743 (UniProtKB)
Alt. Names/Synonyms: 80 kDa diacylglycerol kinase; DAG kinase alpha; DAGK; DAGK1; DGK-alpha; DGKA; Diacylglycerol kinase alpha; diacylglycerol kinase, alpha 80kDa; Diglyceride kinase alpha; MGC12821; MGC42356
Gene Symbols: DGKA
Molecular weight: 82,630 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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