DNCH1 Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression. Belongs to the dynein heavy chain family. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 12 F1|12 60.7 cM
Cellular Component:  axon; cell cortex; centrosome; cytoplasm; cytoplasmic dynein complex; cytoplasmic microtubule; cytoskeleton; dynein complex; filopodium; manchette; microtubule; neuronal cell body; nuclear envelope
Molecular Function:  ATP binding; ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding; dynein light chain binding; dynein light intermediate chain binding; microtubule motor activity; motor activity; nucleotide binding; protein binding
Biological Process:  cell cycle; cell division; cilium movement; cytoplasmic microtubule organization; cytoplasmic mRNA processing body assembly; establishment of spindle localization; microtubule-based movement; minus-end-directed vesicle transport along microtubule; mitotic cell cycle; nuclear migration; positive regulation of cold-induced thermogenesis; positive regulation of intracellular transport; positive regulation of spindle assembly; regulation of metaphase plate congression; regulation of mitotic spindle organization; retrograde axonal transport; stress granule assembly
Reference #:  Q9JHU4 (UniProtKB)
Alt. Names/Synonyms: 9930018I23Rik; AI894280; Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dhc1; DHC1a; Dnch1; Dnchc1; DNCL; Dnec1; Dnecl; Dyhc; DYHC1; Dync1h1; dynein cytoplasmic 1 heavy chain 1; Dynein heavy chain, cytosolic; dynein heavy chain, retrograde transport; dynein, cytoplasmic, heavy chain 1; legs at odd angle; Loa; MAP1C; mKIAA0325; P22; sprawling; Swl
Gene Symbols: Dync1h1
Molecular weight: 532,045 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene