DNCH1 Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression. Belongs to the dynein heavy chain family. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 14q32.31
Cellular Component:  azurophil granule lumen; centrosome; cytoplasmic dynein complex; cytosol; extracellular region; filopodium; microtubule
Molecular Function:  ATP binding; dynein light intermediate chain binding; protein binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; cell division; ciliary basal body-plasma membrane docking; cytoplasmic mRNA processing body assembly; ER to Golgi vesicle-mediated transport; establishment of spindle localization; G2/M transition of mitotic cell cycle; mitotic spindle organization; neutrophil degranulation; positive regulation of cold-induced thermogenesis; positive regulation of intracellular transport; positive regulation of spindle assembly; regulation of G2/M transition of mitotic cell cycle; regulation of metaphase plate congression; regulation of mitotic spindle organization; stress granule assembly
Disease: Charcot-marie-tooth Disease, Axonal, Type 2o; Mental Retardation, Autosomal Dominant 13; Spinal Muscular Atrophy, Lower Extremity-predominant, 1, Autosomal Dominant
Reference #:  Q14204 (UniProtKB)
Alt. Names/Synonyms: CMT2O; Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; DHC1; DHC1a; DKFZp686P2245; DNCH1; Dnchc1; DNCL; DNECL; DYHC; DYHC1; DYNC1H1; dynein cytoplasmic 1 heavy chain 1; Dynein heavy chain, cytosolic; dynein, cytoplasmic 1, heavy chain 1; dynein, cytoplasmic, heavy polypeptide 1; dynein, cytoplasmic-like; HL-3; KIAA0325; p22; SMALED1
Gene Symbols: DYNC1H1
Molecular weight: 532,408 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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