PEAR1 When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. Belongs to the MEGF family. Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of human Ortholog: 1q23.1
Cellular Component:  integral component of membrane; phagocytic cup
Molecular Function:  signaling receptor activity
Biological Process:  phosphatidylinositol 3-kinase signaling; platelet aggregation; protein kinase B signaling; recognition of apoptotic cell
Reference #:  Q5VY43 (UniProtKB)
Alt. Names/Synonyms: FLJ00193; hPEAR1; JEDI; MEGF12; Multiple EGF-like domains protein 12; multiple EGF-like-domains 12; Multiple epidermal growth factor-like domains protein 12; PEAR1; Platelet endothelial aggregation receptor 1
Gene Symbols: PEAR1
Molecular weight: 110,666 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene