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iNOS
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8. Belongs to the NOS family. Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase |
| Chromosomal Location of human Ortholog: 17q11.2 |
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Cellular Component:
cortical cytoskeleton; cytoplasm; cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; peroxisomal matrix; peroxisome; plasma membrane
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Molecular Function:
arginine binding; calmodulin binding; flavin adenine dinucleotide binding; FMN binding; heme binding; metal ion binding; NADP binding; nitric-oxide synthase activity; protein binding; protein homodimerization activity; tetrahydrobiopterin binding
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Biological Process:
arginine catabolic process; cell redox homeostasis; cellular response to lipopolysaccharide; cellular response to type II interferon; cellular response to xenobiotic stimulus; circadian rhythm; defense response to bacterium; defense response to Gram-negative bacterium; inflammatory response; innate immune response in mucosa; negative regulation of blood pressure; negative regulation of gene expression; negative regulation of protein catabolic process; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; peptidyl-cysteine S-nitrosylation; positive regulation of guanylate cyclase activity; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of killing of cells of another organism; positive regulation of leukocyte mediated cytotoxicity; prostaglandin secretion; regulation of cell population proliferation; regulation of cellular respiration; regulation of cytokine production involved in inflammatory response; regulation of insulin secretion; response to bacterium; response to hormone; response to hypoxia; response to lipopolysaccharide; superoxide metabolic process
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Disease: Malaria, Susceptibility To
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Reference #:
P35228
(UniProtKB)
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Alt. Names/Synonyms: HEP-NOS; Hepatocyte NOS; Inducible NO synthase; Inducible NOS; iNOS; nitric oxide synthase 2; nitric oxide synthase 2, inducible; nitric oxide synthase 2A (inducible, hepatocytes); Nitric oxide synthase, inducible; nitric oxide synthase, macrophage; NOS; NOS type II; NOS, type II; NOS2; NOS2A; Peptidyl-cysteine S-nitrosylase NOS2
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Gene Symbols: NOS2
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Molecular weight:
131,117 Da
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Basal Isoelectric point:
8.2
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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Insulin Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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