iNOS Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8. Belongs to the NOS family. Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component:  cortical cytoskeleton; cytoplasm; cytosol; nucleus; perinuclear region of cytoplasm; peroxisomal matrix; peroxisome
Molecular Function:  arginine binding; calmodulin binding; flavin adenine dinucleotide binding; FMN binding; heme binding; metal ion binding; NADP binding; nitric-oxide synthase activity; protein binding; protein homodimerization activity; signaling receptor binding; tetrahydrobiopterin binding
Biological Process:  arginine catabolic process; cell redox homeostasis; cellular response to drug; cellular response to interferon-gamma; cellular response to lipopolysaccharide; circadian rhythm; cytokine-mediated signaling pathway; defense response to bacterium; defense response to Gram-negative bacterium; innate immune response in mucosa; interleukin-6 secretion; interleukin-8 secretion; negative regulation of gene expression; negative regulation of protein catabolic process; nitric oxide biosynthetic process; oxidation-reduction process; peptidyl-cysteine S-nitrosylation; positive regulation of killing of cells of other organism; positive regulation of leukocyte mediated cytotoxicity; prostaglandin secretion; protein targeting to peroxisome; regulation of cell proliferation; regulation of cellular respiration; regulation of cytokine production involved in inflammatory response; regulation of insulin secretion; response to bacterium; response to hypoxia; superoxide metabolic process
Disease: Malaria, Susceptibility To
Reference #:  P35228 (UniProtKB)
Alt. Names/Synonyms: HEP-NOS; Hepatocyte NOS; Inducible NO synthase; Inducible NOS; iNOS; nitric oxide synthase 2, inducible; nitric oxide synthase 2A (inducible, hepatocytes); Nitric oxide synthase, inducible; nitric oxide synthase, macrophage; NOS; NOS type II; NOS, type II; NOS2; NOS2A
Gene Symbols: NOS2
Molecular weight: 131,117 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene