iNOS Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8. Belongs to the NOS family. Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 11 B5|11 46.74 cM
Cellular Component:  cortical cytoskeleton; cytoplasm; cytosol; extracellular space; nucleus; perinuclear region of cytoplasm; peroxisome; plasma membrane; vesicle membrane
Molecular Function:  actin binding; arginine binding; beta-catenin binding; cadherin binding; calmodulin binding; cAMP-dependent protein kinase regulator activity; flavin adenine dinucleotide binding; FMN binding; heme binding; Hsp90 protein binding; metal ion binding; NADP binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; nitric-oxide synthase binding; oxidoreductase activity; protein binding; protein homodimerization activity; protein kinase binding; signaling receptor binding; tetrahydrobiopterin binding
Biological Process:  arginine catabolic process; cellular response to cytokine stimulus; cellular response to drug; cellular response to interferon-gamma; cellular response to lipopolysaccharide; cellular response to organic cyclic compound; circadian rhythm; defense response to bacterium; inflammatory response; interleukin-6 secretion; interleukin-8 secretion; negative regulation of blood pressure; negative regulation of gene expression; negative regulation of protein catabolic process; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; oxidation-reduction process; peptidyl-cysteine S-nitrosylation; positive regulation of guanylate cyclase activity; positive regulation of killing of cells of other organism; prostaglandin secretion; regulation of cell proliferation; regulation of cytokine production involved in inflammatory response; regulation of insulin secretion; response to bacterium; response to hormone; response to hypoxia; response to lipopolysaccharide; superoxide metabolic process
Reference #:  P29477 (UniProtKB)
Alt. Names/Synonyms: i-NOS; inducible nitric oxide synthase; Inducible NO synthase; Inducible NOS; iNOS; Inosl; MAC-NOS; Macrophage NOS; nitric oxide synthase 2, inducible; nitric oxide synthase 2, inducible, macrophage; Nitric oxide synthase, inducible; NOS type II; Nos-2; NOS-II; Nos2; Nos2a; OTTMUSP00000000202; Peptidyl-cysteine S-nitrosylase NOS2
Gene Symbols: Nos2
Molecular weight: 130,575 Da
Basal Isoelectric point: 7.76  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene