RIP140 Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 21q11.2-q21.1
Cellular Component:  chromatin; cytosol; fibrillar center; histone deacetylase complex; nuclear speck; nucleolus; nucleoplasm; nucleus
Molecular Function:  histone deacetylase binding; nuclear estrogen receptor binding; nuclear glucocorticoid receptor binding; nuclear receptor binding; nuclear retinoid X receptor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; signaling receptor binding; transcription coactivator activity; transcription corepressor activity
Biological Process:  cellular response to estradiol stimulus; circadian regulation of gene expression; circadian rhythm; DNA-templated transcription; lipid storage; negative regulation of transcription by RNA polymerase II; ovarian follicle rupture; positive regulation of transcription by RNA polymerase II
Disease: Congenital Anomalies Of Kidney And Urinary Tract 3
Reference #:  P48552 (UniProtKB)
Alt. Names/Synonyms: CAKUT3; FLJ77253; NRIP1; Nuclear factor RIP140; nuclear receptor interacting protein 1; Nuclear receptor-interacting protein 1; receptor interacting protein 140; Receptor-interacting protein 140; RIP140
Gene Symbols: NRIP1
Molecular weight: 126,942 Da
Basal Isoelectric point: 8.36  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB