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RIP140
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 21q11.2-q21.1 |
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Cellular Component:
chromatin; cytosol; fibrillar center; histone deacetylase complex; nuclear speck; nucleolus; nucleoplasm; nucleus
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Molecular Function:
histone deacetylase binding; nuclear estrogen receptor binding; nuclear glucocorticoid receptor binding; nuclear receptor binding; nuclear retinoid X receptor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; signaling receptor binding; transcription coactivator activity; transcription corepressor activity
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Biological Process:
cellular response to estradiol stimulus; circadian regulation of gene expression; circadian rhythm; DNA-templated transcription; lipid storage; negative regulation of transcription by RNA polymerase II; ovarian follicle rupture; positive regulation of transcription by RNA polymerase II
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Disease: Congenital Anomalies Of Kidney And Urinary Tract 3
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Reference #:
P48552
(UniProtKB)
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Alt. Names/Synonyms: CAKUT3; FLJ77253; NRIP1; Nuclear factor RIP140; nuclear receptor interacting protein 1; Nuclear receptor-interacting protein 1; receptor interacting protein 140; Receptor-interacting protein 140; RIP140
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Gene Symbols: NRIP1
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Molecular weight:
126,942 Da
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Basal Isoelectric point:
8.36
Predict pI for various phosphorylation states
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