RIP140 Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16|16 C3.1
Cellular Component:  histone deacetylase complex; nuclear chromatin; nuclear speck; nucleolus; nucleus
Molecular Function:  estrogen receptor binding; glucocorticoid receptor binding; histone deacetylase binding; nuclear hormone receptor binding; protein binding; retinoic acid receptor binding; retinoid X receptor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; signaling receptor binding; transcription coactivator activity; transcription coregulator activity; transcription corepressor activity
Biological Process:  cellular response to estradiol stimulus; circadian regulation of gene expression; lipid storage; negative regulation of transcription by RNA polymerase II; ovarian follicle rupture; ovulation; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; rhythmic process
Reference #:  Q8CBD1 (UniProtKB)
Alt. Names/Synonyms: 6030458L20Rik; 8430438I05Rik; 9630050P12; AA959574; AW456757; Nrip1; Nuclear factor RIP140; nuclear receptor interacting protein 1; Nuclear receptor-interacting protein 1; Receptor-interacting protein 140; RIP140
Gene Symbols: Nrip1
Molecular weight: 126,337 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA