HDAC3 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation. Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress. Regulates both the transcriptional activation and repression phases of the circadian clock in a deacetylase activity-independent manner. During the activation phase, promotes the accumulation of ubiquitinated ARNTL/BMAL1 at the E-boxes and during the repression phase, blocks FBXL3-mediated CRY1/2 ubiquitination and promotes the interaction of CRY1 and ARNTL/BMAL1. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver. Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding. In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response. Belongs to the histone deacetylase family. HD type 1 subfamily. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Deacetylase; EC; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 18 19.81 cM|18 B3
Cellular Component:  chromatin; cytoplasm; cytosol; Golgi apparatus; histone deacetylase complex; mitotic spindle; nucleoplasm; nucleus; plasma membrane; transcription repressor complex
Molecular Function:  chromatin binding; chromatin DNA binding; cyclin binding; deacetylase activity; DNA binding; DNA-binding transcription factor binding; enzyme binding; GTPase binding; histone deacetylase activity; histone deacetylase binding; histone decrotonylase activity; hydrolase activity; NF-kappaB binding; protein binding; protein de-2-hydroxyisobutyrylase activity; protein decrotonylase activity; protein lysine deacetylase activity; transcription corepressor activity; transcription corepressor binding; transcription factor binding
Biological Process:  cellular response to fluid shear stress; chromatin organization; circadian regulation of gene expression; cornified envelope assembly; epidermis development; establishment of mitotic spindle orientation; establishment of skin barrier; gene expression; histone deacetylation; in utero embryonic development; negative regulation of cardiac muscle cell differentiation; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of interleukin-1 production; negative regulation of JNK cascade; negative regulation of protein export from nucleus; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor production; positive regulation of cold-induced thermogenesis; positive regulation of neuron apoptotic process; positive regulation of protein import into nucleus; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of TOR signaling; positive regulation of transcription by RNA polymerase II; positive regulation of type B pancreatic cell apoptotic process; protein deacetylation; regulation of circadian rhythm; regulation of mitotic cell cycle; regulation of multicellular organism growth; regulation of protein stability; rhythmic process; spindle assembly; transcription by RNA polymerase II
Reference #:  O88895 (UniProtKB)
Alt. Names/Synonyms: AW537363; HD3; Hdac3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; Histone deacetylase 3; OTTMUSP00000018789
Gene Symbols: Hdac3
Molecular weight: 48,821 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein