GAB2 Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Belongs to the GAB family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of rat Ortholog: 1q32
Cellular Component:  cytoplasm; plasma membrane; protein-containing complex
Molecular Function:  phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein domain specific binding; protein phosphatase binding; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  cell migration; integrin-mediated signaling pathway; intracellular signal transduction; osteoclast differentiation; phosphatidylinositol-mediated signaling; positive regulation of cell proliferation; positive regulation of epithelial cell migration; positive regulation of mast cell degranulation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q9EQH1 (UniProtKB)
Alt. Names/Synonyms: Gab2; GRB2-associated binder 2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; Growth factor receptor bound protein 2-associated protein 2
Gene Symbols: Gab2
Molecular weight: 73,328 Da
Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  PI3K/Akt Signaling
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene