MDM4 Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. Belongs to the MDM2/MDM4 family. Expressed in all tissues tested with high levels in thymus. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1 E4|1 57.75 cM
Cellular Component:  nucleus
Molecular Function:  enzyme binding; metal ion binding; protein binding
Biological Process:  atrial septum development; atrioventricular valve morphogenesis; endocardial cushion morphogenesis; heart valve development; negative regulation of apoptotic process; negative regulation of cell cycle arrest; negative regulation of protein catabolic process; negative regulation of transcription by RNA polymerase II; positive regulation of cell proliferation; protein-containing complex assembly; regulation of heart rate; ventricular septum development
Reference #:  O35618 (UniProtKB)
Alt. Names/Synonyms: 4933417N07Rik; AA414968; AL023055; AU018793; AU021806; C85810; Double minute 4 protein; Mdm2-like p53-binding protein; Mdm4; Mdmx; p53-binding protein Mdm4; Protein Mdm4; Protein Mdmx; transformed mouse 3T3 cell double minute 4
Gene Symbols: Mdm4
Molecular weight: 54,963 Da
Basal Isoelectric point: 5.17  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene