PRKX Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: Xp22.33
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; cAMP-dependent protein kinase activity; protein binding
Biological Process:  angiogenesis; cell adhesion; cell-substrate adhesion; endothelial cell migration; endothelial cell proliferation; epithelial tube morphogenesis; kidney morphogenesis; myeloid cell differentiation; peptidyl-serine phosphorylation; protein autophosphorylation; regulation of cell adhesion; regulation of cell migration; regulation of epithelial cell differentiation involved in kidney development
Reference #:  P51817 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase catalytic subunit PRKX; PKX1; PRKX; Protein kinase PKX1; protein kinase, X-linked; Serine/threonine-protein kinase PRKX
Gene Symbols: PRKX
Molecular weight: 40,896 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene