SLC22A1 Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 1q11
Cellular Component:  basolateral plasma membrane; integral component of plasma membrane
Molecular Function:  acetylcholine transmembrane transporter activity; dopamine:sodium symporter activity; identical protein binding; monoamine transmembrane transporter activity; norepinephrine:sodium symporter activity; organic cation transmembrane transporter activity; protein homodimerization activity; quaternary ammonium group transmembrane transporter activity; secondary active organic cation transmembrane transporter activity
Biological Process:  acetate ester transport; ammonium transmembrane transport; cation transport; dopamine transport; dopamine uptake; drug transmembrane transport; epinephrine transport; establishment or maintenance of transmembrane electrochemical gradient; monoamine transport; neurotransmitter transport; norepinephrine transport; norepinephrine uptake; organic cation transport; protein homooligomerization; quaternary ammonium group transport
Reference #:  Q63089 (UniProtKB)
Alt. Names/Synonyms: MGC93570; Oct1; Orct1; Organic cation transporter 1; rOCT1; S22A1; Slc22a1; solute carrier family 22 (organic cation transporter), member 1; Solute carrier family 22 member 1; solute carrier family 22, member 1
Gene Symbols: Slc22a1
Molecular weight: 61,541 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene