EphA6 Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Expressed in brain and testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 3q11.2
Cellular Component:  nucleoplasm; plasma membrane
Molecular Function:  ATP binding
Biological Process:  ephrin receptor signaling pathway; peptidyl-tyrosine phosphorylation
Reference #:  Q9UF33 (UniProtKB)
Alt. Names/Synonyms: DKFZp434C1418; EHK-2; EHK2; EK12; EPA6; EPH homology kinase 2; EPH receptor A6; EPH-like kinase 12; EPHA6; ephrin receptor EphA6; Ephrin type-A receptor 6; FLJ35246; HEK12; PRO57066
Gene Symbols: EPHA6
Molecular weight: 116,379 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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EphA6

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene