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NDUFA10
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFA10 subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase |
| Chromosomal Location of human Ortholog: 2q37.3 |
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Cellular Component:
cytoplasm; mitochondrial inner membrane; mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion
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Molecular Function:
NADH dehydrogenase (ubiquinone) activity
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Biological Process:
aerobic respiration; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; proton motive force-driven mitochondrial ATP synthesis
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Disease: Mitochondrial Complex I Deficiency, Nuclear Type 22
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Reference #:
O95299
(UniProtKB)
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Alt. Names/Synonyms: CI-42k; CI-42kD; complex I 42kDa subunit; Complex I-42kD; FLJ21923; MC1DN22; MGC5103; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; NADH-ubiquinone oxidoreductase 42 kDa subunit; NADH:ubiquinone oxidoreductase subunit A10; NDUAA; NDUFA10
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Gene Symbols: NDUFA10
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Molecular weight:
40,751 Da
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Basal Isoelectric point:
8.67
Predict pI for various phosphorylation states
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