VAV3 Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion. Isoform 1 and isoform 3 are widely expressed; both are expressed at very low levels in skeletal muscle. In keratinocytes, isoform 1 is less abundant than isoform 3. Isoform 3 is detected at very low levels, if any, in adrenal gland, bone marrow, spleen, fetal brain and spinal chord; in these tissues, isoform 1 is readily detectable. 4 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p13.3
Cellular Component:  cytosol; plasma membrane
Molecular Function:  epidermal growth factor receptor binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding; Rac guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity
Biological Process:  angiogenesis; B cell receptor signaling pathway; cellular response to DNA damage stimulus; ephrin receptor signaling pathway; Fc-epsilon receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; G protein-coupled receptor signaling pathway; integrin-mediated signaling pathway; lamellipodium assembly; neutrophil chemotaxis; platelet activation; positive regulation of apoptotic process; positive regulation of B cell proliferation; positive regulation of cell adhesion; positive regulation of GTPase activity; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of signal transduction; regulation of cell size; regulation of GTPase activity; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; response to drug; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway; vesicle fusion
Reference #:  Q9UKW4 (UniProtKB)
Alt. Names/Synonyms: FLJ40431; Guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3; VAV3
Gene Symbols: VAV3
Molecular weight: 97,776 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein