NET1 Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 13|13 A1
Cellular Component:  cytoplasm; nucleus; plasma membrane
Molecular Function:  GTP-Rho binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  cellular response to hydrogen peroxide; cellular response to ionizing radiation; intracellular signal transduction; myoblast migration; positive regulation of apoptotic process; positive regulation of GTPase activity; positive regulation of substrate adhesion-dependent cell spreading; regulation of Rho protein signal transduction
Reference #:  Q9Z206 (UniProtKB)
Alt. Names/Synonyms: 0610025H04Rik; 9530071N24Rik; AI604373; ARHG8; Arhgef8; AU015857; guanine nucleotide regulatory protein (oncogene); mNET; mNET1; Net1; Net1 homolog; Net1a; neuroepithelial cell transforming gene 1; Neuroepithelial cell-transforming gene 1 protein; Rho guanine nucleotide exchange factor 8
Gene Symbols: Net1
Molecular weight: 67,734 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene