TRPC5 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily. Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: Xq23
Cellular Component:  calcium channel complex; cation channel complex; cytoplasm; dendrite; growth cone; membrane raft; neuronal cell body; plasma membrane
Molecular Function:  actin binding; actinin binding; ATPase binding; calcium channel activity; clathrin binding; inositol 1,4,5 trisphosphate binding; protein binding; store-operated calcium channel activity
Biological Process:  calcium ion transmembrane transport; calcium ion transport; manganese ion transport; negative regulation of dendrite morphogenesis; nervous system development; neuron apoptotic process; neuron differentiation; phosphatidylserine exposure on apoptotic cell surface; positive regulation of axon extension; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of neuron differentiation; positive regulation of peptidyl-threonine phosphorylation; regulation of cytosolic calcium ion concentration; regulation of membrane hyperpolarization
Reference #:  Q9UL62 (UniProtKB)
Alt. Names/Synonyms: hTRP-5; hTRP5; PPP1R159; protein phosphatase 1, regulatory subunit 159; Short transient receptor potential channel 5; transient receptor potential cation channel subfamily C member 5; transient receptor potential cation channel, subfamily C, member 5; transient receptor potential channel 5; Transient receptor protein 5; TRP-5; TRP5; TRPC5
Gene Symbols: TRPC5
Molecular weight: 111,412 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene