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TRPC5
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily. Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. Note: This description may include information from UniProtKB.
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| Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: Xq23 |
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Cellular Component:
calcium channel complex; cation channel complex; cytoplasm; dendrite; growth cone; membrane raft; neuronal cell body; plasma membrane
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Molecular Function:
actin binding; actinin binding; ATPase binding; calcium channel activity; clathrin binding; inositol 1,4,5 trisphosphate binding; protein binding; store-operated calcium channel activity
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Biological Process:
calcium ion transmembrane transport; calcium ion transport; manganese ion transport; negative regulation of dendrite morphogenesis; nervous system development; neuron apoptotic process; neuron differentiation; phosphatidylserine exposure on apoptotic cell surface; positive regulation of axon extension; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of neuron differentiation; positive regulation of peptidyl-threonine phosphorylation; regulation of cytosolic calcium ion concentration; regulation of membrane hyperpolarization
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Reference #:
Q9UL62
(UniProtKB)
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Alt. Names/Synonyms: hTRP-5; hTRP5; PPP1R159; protein phosphatase 1, regulatory subunit 159; Short transient receptor potential channel 5; transient receptor potential cation channel subfamily C member 5; transient receptor potential cation channel, subfamily C, member 5; transient receptor potential channel 5; Transient receptor protein 5; TRP-5; TRP5; TRPC5
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Gene Symbols: TRPC5
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Molecular weight:
111,412 Da
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Basal Isoelectric point:
6.94
Predict pI for various phosphorylation states
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