TRPC5 Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily. Expressed in brain with higher levels in fetal brain. Found in cerebellum and occipital pole. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: X F2|X 65.49 cM
Cellular Component:  calcium channel complex; cation channel complex; cytoplasm; dendrite; growth cone; integral component of membrane; integral component of plasma membrane; membrane; membrane raft; neuronal cell body; plasma membrane
Molecular Function:  actin binding; actinin binding; ATPase binding; calcium channel activity; clathrin binding; inositol 1,4,5 trisphosphate binding; ion channel activity; protein binding; store-operated calcium channel activity
Biological Process:  calcium ion transmembrane transport; calcium ion transport; ion transport; manganese ion transport; negative regulation of dendrite morphogenesis; positive regulation of axon extension; positive regulation of cell proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of neuron differentiation; positive regulation of peptidyl-threonine phosphorylation; regulation of cytosolic calcium ion concentration; regulation of membrane hyperpolarization; transmembrane transport
Reference #:  Q9QX29 (UniProtKB)
Alt. Names/Synonyms: Capacitative calcium entry channel 2; CCE2; MGC124500; mTRP5; OTTMUSP00000020456; Short transient receptor potential channel 5; transient receptor potential cation channel, subfamily C, member 5; Transient receptor protein 5; TRP-5; Trp-related protein 5; Trp5; TrpC5; Trrp5; vtransient receptor potential cation channel, subfamily C, member 5
Gene Symbols: Trpc5
Molecular weight: 111,458 Da
Basal Isoelectric point: 7.53  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene