UGT1A7 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. Belongs to the UDP-glycosyltransferase family. Liver and gastric tissue. Isoform 1 and isoform 2 are expressed in esophagus. Neither isoform is expressed in liver, kidney, colon and small intestine (PubMed:18004212). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of human Ortholog: 2q37.1
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane
Molecular Function:  enzyme binding; enzyme inhibitor activity; glucuronosyltransferase activity; protein homodimerization activity; protein kinase C binding; retinoic acid binding
Biological Process:  cellular glucuronidation; coumarin metabolic process; estrogen metabolic process; flavone metabolic process; flavonoid glucuronidation; liver development; negative regulation of catalytic activity; retinoic acid metabolic process; xenobiotic glucuronidation; xenobiotic metabolic process
Reference #:  Q9HAW7 (UniProtKB)
Alt. Names/Synonyms: Bilirubin-specific UDPGT isozyme 1; GNT1; hUG-BR1; UD17; UDP glucuronosyltransferase 1 family, polypeptide A7; UDP glucuronosyltransferase family 1 member A7; UDP glycosyltransferase 1 family, polypeptide A7; UDP-glucuronosyltransferase 1 family polypeptide A7s; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-7; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1-G; UDP-glucuronosyltransferase 1A1; UDP-glucuronosyltransferase 1A7; UDPGT; UDPGT 1-1; UDPGT 1-7; UGT-1A; UGT-1G; UGT1; UGT1*7; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A; UGT1A1; UGT1A7; UGT1G
Gene Symbols: UGT1A7
Molecular weight: 59,819 Da
Basal Isoelectric point: 7.88  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

UGT1A7

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene