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UGT1A7
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. Belongs to the UDP-glycosyltransferase family. Liver and gastric tissue. Isoform 1 and isoform 2 are expressed in esophagus. Neither isoform is expressed in liver, kidney, colon and small intestine (PubMed:18004212). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 |
| Chromosomal Location of human Ortholog: 2q37.1 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane
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Molecular Function:
enzyme binding; enzyme inhibitor activity; glucuronosyltransferase activity; protein homodimerization activity; protein kinase C binding; retinoic acid binding
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Biological Process:
cellular glucuronidation; coumarin metabolic process; estrogen metabolic process; flavone metabolic process; flavonoid glucuronidation; liver development; negative regulation of catalytic activity; retinoic acid metabolic process; xenobiotic glucuronidation; xenobiotic metabolic process
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Reference #:
Q9HAW7
(UniProtKB)
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Alt. Names/Synonyms: Bilirubin-specific UDPGT isozyme 1; GNT1; hUG-BR1; UD17; UDP glucuronosyltransferase 1 family, polypeptide A7; UDP glucuronosyltransferase family 1 member A7; UDP glycosyltransferase 1 family, polypeptide A7; UDP-glucuronosyltransferase 1 family polypeptide A7s; UDP-glucuronosyltransferase 1-1; UDP-glucuronosyltransferase 1-7; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1-G; UDP-glucuronosyltransferase 1A1; UDP-glucuronosyltransferase 1A7; UDPGT; UDPGT 1-1; UDPGT 1-7; UGT-1A; UGT-1G; UGT1; UGT1*7; UGT1-01; UGT1-07; UGT1.1; UGT1.7; UGT1A; UGT1A1; UGT1A7; UGT1G
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Gene Symbols: UGT1A7
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Molecular weight:
59,819 Da
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Basal Isoelectric point:
7.88
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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