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GATA2
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of mouse Ortholog: 6 D1|6 39.2 cM |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
C2H2 zinc finger domain binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription coactivator binding; transcription coregulator binding; zinc ion binding
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Biological Process:
angiogenesis; brown fat cell differentiation; cell differentiation in hindbrain; cell fate commitment; cell fate determination; central nervous system neuron development; commitment of neuronal cell to specific neuron type in forebrain; definitive hemopoiesis; embryonic placenta development; eosinophil fate commitment; fat cell differentiation; GABAergic neuron differentiation; glandular epithelial cell differentiation; glandular epithelial cell maturation; hematopoietic progenitor cell differentiation; hematopoietic stem cell homeostasis; homeostasis of number of cells within a tissue; inner ear morphogenesis; myeloid cell differentiation; negative regulation of brown fat cell differentiation; negative regulation of endothelial cell apoptotic process; negative regulation of gene expression; negative regulation of hematopoietic progenitor cell differentiation; negative regulation of macrophage differentiation; negative regulation of myeloid cell differentiation; negative regulation of neural precursor cell proliferation; negative regulation of neuroblast proliferation; negative regulation of Notch signaling pathway; negative regulation of transcription by RNA polymerase II; neural precursor cell proliferation; neuroblast proliferation; neuroendocrine cell differentiation; neuron differentiation; neuron fate commitment; neuron maturation; neuron migration; phagocytosis; pituitary gland development; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of mast cell degranulation; positive regulation of megakaryocyte differentiation; positive regulation of miRNA transcription; positive regulation of neuron differentiation; positive regulation of phagocytosis; positive regulation of phagocytosis, engulfment; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of forebrain neuron differentiation; regulation of histone acetylation; regulation of primitive erythrocyte differentiation; regulation of transcription by RNA polymerase II; semicircular canal development; somatic stem cell population maintenance; thyroid-stimulating hormone-secreting cell differentiation; transcription by RNA polymerase II; urogenital system development; vascular wound healing; ventral spinal cord interneuron differentiation
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Reference #:
O09100
(UniProtKB)
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Alt. Names/Synonyms: Endothelial transcription factor GATA-2; Gata; GATA binding protein 2; Gata-2; GATA-binding protein 2; Gata2; MGC129339
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Gene Symbols: Gata2
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Molecular weight:
50,468 Da
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Basal Isoelectric point:
9.43
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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