GATA2 Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component:  cytoplasm; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  C2H2 zinc finger domain binding; chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enhancer sequence-specific DNA binding; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; transcription factor binding; zinc ion binding
Biological Process:  blood coagulation; cell differentiation in hindbrain; cell fate determination; cell maturation; central nervous system neuron development; cochlea development; commitment of neuronal cell to specific neuron type in forebrain; definitive hemopoiesis; embryonic placenta development; eosinophil fate commitment; GABAergic neuron differentiation; homeostasis of number of cells within a tissue; inner ear morphogenesis; negative regulation of endothelial cell apoptotic process; negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; negative regulation of gene expression; negative regulation of macrophage differentiation; negative regulation of neural precursor cell proliferation; negative regulation of Notch signaling pathway; negative regulation of transcription by RNA polymerase II; neuron migration; phagocytosis; pituitary gland development; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of erythrocyte differentiation; positive regulation of gene expression; positive regulation of mast cell degranulation; positive regulation of megakaryocyte differentiation; positive regulation of neuron differentiation; positive regulation of phagocytosis; positive regulation of phagocytosis, engulfment; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of forebrain neuron differentiation; regulation of hematopoietic stem cell differentiation; regulation of histone acetylation; regulation of primitive erythrocyte differentiation; response to lipid; semicircular canal development; somatic stem cell population maintenance; transcription, DNA-templated; urogenital system development; ventral spinal cord interneuron differentiation
Disease: Immunodeficiency 21; Leukemia, Acute Myeloid; Lymphedema, Primary, With Myelodysplasia; Myelodysplastic Syndrome
Reference #:  P23769 (UniProtKB)
Alt. Names/Synonyms: DCML; Endothelial transcription factor GATA-2; FLJ45948; GATA binding protein 2; GATA-binding protein 2; GATA2; IMD21; MGC2306; MONOMAC; NFE1B
Gene Symbols: GATA2
Molecular weight: 50,500 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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