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PKG2
Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. Highly concentrated in brain, lung and intestinal mucosa. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; EC 2.7.11.12; Kinase, protein; PKG family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 4q21.21 |
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Cellular Component:
apical plasma membrane; cytosol; nuclear membrane
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Molecular Function:
ATP binding; cGMP binding; cGMP-dependent protein kinase activity; identical protein binding; mitogen-activated protein kinase binding; protein kinase activity; protein serine kinase activity
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Biological Process:
negative regulation of chloride transport; peptidyl-serine autophosphorylation; positive regulation of chondrocyte differentiation; positive regulation of protein localization; protein localization to plasma membrane; protein phosphorylation; signal transduction; tetrahydrobiopterin metabolic process
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Disease: Acromesomelic Dysplasia 4; Spondylometaphyseal Dysplasia, Pagnamenta Type
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Reference #:
Q13237
(UniProtKB)
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Alt. Names/Synonyms: cGK 2; cGK2; cGKII; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; KGP2; PKG2; PRKG2; PRKGR2; protein kinase cGMP-dependent 2; protein kinase, cGMP-dependent, type II; testicular tissue protein Li 99
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Gene Symbols: PRKG2
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Molecular weight:
87,432 Da
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Basal Isoelectric point:
8.67
Predict pI for various phosphorylation states
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