NKCC1 Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Belongs to the SLC12A transporter family. Expressed in many tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of mouse Ortholog: 18 D3|18 32.15 cM
Cellular Component:  apical plasma membrane; basal plasma membrane; basolateral plasma membrane; cell body; cell periphery; cell projection; cytoplasmic vesicle membrane; lateral plasma membrane; membrane; neuron projection; neuronal cell body; plasma membrane
Molecular Function:  ammonium transmembrane transporter activity; chloride:monoatomic cation symporter activity; Hsp90 protein binding; metal ion transmembrane transporter activity; potassium ion transmembrane transporter activity; protein binding; protein kinase binding; protein-folding chaperone binding; sodium:potassium:chloride symporter activity; symporter activity; transmembrane transporter activity
Biological Process:  ammonium transmembrane transport; branching involved in mammary gland duct morphogenesis; cell volume homeostasis; cellular response to chemokine; cellular response to lipopolysaccharide; cellular response to potassium ion; chloride ion homeostasis; chloride transmembrane transport; chloride transport; detection of mechanical stimulus involved in sensory perception of sound; gamma-aminobutyric acid signaling pathway; hyperosmotic response; inorganic anion import across plasma membrane; inorganic cation import across plasma membrane; intracellular chloride ion homeostasis; intracellular potassium ion homeostasis; intracellular sodium ion homeostasis; maintenance of blood-brain barrier; mammary duct terminal end bud growth; monoatomic ion transport; multicellular organism growth; negative regulation of vascular wound healing; positive regulation of aspartate secretion; positive regulation of cell volume; potassium ion homeostasis; potassium ion import across plasma membrane; potassium ion transport; regulation of matrix metallopeptidase secretion; regulation of spontaneous synaptic transmission; sodium ion homeostasis; sodium ion import across plasma membrane; sodium ion transmembrane transport; sodium ion transport; T cell chemotaxis; transepithelial ammonium transport; transepithelial chloride transport; transmembrane transport
Reference #:  P55012 (UniProtKB)
Alt. Names/Synonyms: 9330166H04R; 9330166H04Rik; Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; mBSC; mBSC2; Nkcc; Nkcc1; S12A2; Slc12a2; sodium/potassium/chloride cotransporters; sodium/potassium/chloride transporters; Solute carrier family 12 member 2; solute carrier family 12, member 2; sy-ns
Gene Symbols: Slc12a2
Molecular weight: 131,034 Da
Basal Isoelectric point: 6.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene