NKCC1 Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Belongs to the SLC12A transporter family. Expressed in many tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 18 D3|18 32.15 cM
Cellular Component:  apical plasma membrane; basolateral plasma membrane; integral component of membrane; membrane; plasma membrane
Molecular Function:  ammonium transmembrane transporter activity; cation:chloride symporter activity; potassium:chloride symporter activity; protein binding; protein kinase binding; sodium ion transmembrane transporter activity; sodium:chloride symporter activity; sodium:potassium:chloride symporter activity; symporter activity
Biological Process:  ammonium transport; branching involved in mammary gland duct morphogenesis; cell volume homeostasis; cellular response to chemokine; chloride ion homeostasis; chloride transmembrane transport; chloride transport; detection of mechanical stimulus involved in sensory perception of sound; hyperosmotic response; ion transport; mammary duct terminal end bud growth; multicellular organism growth; positive regulation of cell volume; potassium ion homeostasis; potassium ion import across plasma membrane; potassium ion transport; sodium ion homeostasis; sodium ion transmembrane transport; sodium ion transport; T cell chemotaxis; transepithelial ammonium transport; transepithelial chloride transport; transmembrane transport
Reference #:  P55012 (UniProtKB)
Alt. Names/Synonyms: 9330166H04R; 9330166H04Rik; Basolateral Na-K-Cl symporter; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; mBSC; mBSC2; Nkcc; Nkcc1; S12A2; Slc12a2; sodium/potassium/chloride cotransporters; sodium/potassium/chloride transporters; Solute carrier family 12 member 2; solute carrier family 12, member 2; sy-ns
Gene Symbols: Slc12a2
Molecular weight: 131,034 Da
Basal Isoelectric point: 6.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene