TOB1 Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay. Belongs to the BTG family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell cycle regulation
Chromosomal Location of mouse Ortholog: 11|11 D
Cellular Component:  CCR4-NOT complex; cytoplasm; nucleus
Molecular Function:  protein binding; receptor tyrosine kinase binding; SMAD binding; transcription corepressor activity
Biological Process:  negative regulation of BMP signaling pathway; negative regulation of cell population proliferation; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of osteoblast differentiation; negative regulation of translation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; regulation of gene expression; regulation of SMAD protein signal transduction
Reference #:  Q61471 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000001617; Protein Tob1; Tob; Tob1; Transducer of erbB-2 1; transducer of ErbB-2.1; transducer of erbB2; Trob
Gene Symbols: Tob1
Molecular weight: 40,056 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein