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ARRB1
an arrestin protein of the beta-arrestin protein family that function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating receptor desensitization. Also play roles in receptor resensitization processes. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 7 E1|7 54.09 cM |
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Cellular Component:
basolateral plasma membrane; cell projection; chromatin; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; cytosol; dendritic spine; endosome; intracellular anatomical structure; membrane; nuclear body; nucleoplasm; nucleus; plasma membrane; postsynaptic membrane; pseudopodium
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Molecular Function:
alpha-1A adrenergic receptor binding; alpha-1B adrenergic receptor binding; angiotensin receptor binding; AP-2 adaptor complex binding; arrestin family protein binding; clathrin adaptor activity; clathrin binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; enzyme binding; follicle-stimulating hormone receptor binding; G protein-coupled receptor binding; GTPase activator activity; insulin-like growth factor receptor binding; mitogen-activated protein kinase kinase binding; nuclear estrogen receptor binding; phosphoprotein binding; protein binding; protein phosphorylated amino acid binding; signaling receptor binding; transcription coactivator activity; transmembrane transporter binding; ubiquitin protein ligase binding; V2 vasopressin receptor binding
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Biological Process:
endocytosis; follicle-stimulating hormone signaling pathway; G protein-coupled receptor internalization; G protein-coupled receptor signaling pathway; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of GTPase activity; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of neuron apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; negative regulation of protein phosphorylation; negative regulation of protein ubiquitination; negative regulation of signal transduction; phototransduction; positive regulation of cell population proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of histone acetylation; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of receptor internalization; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle cell apoptotic process; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein transport; protein ubiquitination; regulation of apoptotic process; regulation of DNA-templated transcription; regulation of G protein-coupled receptor signaling pathway; regulation of transcription by RNA polymerase II; signal transduction; stress fiber assembly; ubiquitin-dependent protein catabolic process; visual perception
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Reference #:
Q8BWG8
(UniProtKB)
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Alt. Names/Synonyms: 1200006I17Rik; Arrb1; Arrestin beta-1; arrestin, beta 1; arrestin, beta 1, isoform B; AW208571; Beta-arrestin-1; beta-arrestin1; G430100A01Rik; MGC124269; MGC124270
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Gene Symbols: Arrb1
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Molecular weight:
46,973 Da
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Basal Isoelectric point:
5.9
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Hedgehog Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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