ephexin-1 Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension. Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase. Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho
Chromosomal Location of Human Ortholog: 1 D|1 44.42 cM
Cellular Component:  cell projection; cytoplasm; glutamatergic synapse; membrane
Molecular Function:  ephrin receptor binding; guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  cell differentiation; cellular process; ephrin receptor signaling pathway; multicellular organism development; negative regulation of dendritic spine morphogenesis; nervous system development; regulation of GTPase activity; regulation of Rho protein signal transduction; synapse pruning
Reference #:  Q8CHT1 (UniProtKB)
Alt. Names/Synonyms: Eph-interacting exchange protein; ephexin; Ephexin-1; Neuronal guanine nucleotide exchange factor; Ngef; Tims2; transforming immortalised mammary epithelial sequence 2
Gene Symbols: Ngef
Molecular weight: 82,199 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene