DGAT1 Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC; EC; Lipid Metabolism - glycerolipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of Human Ortholog: 15 D3|15 35.99 cM
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; intracellular membrane-bounded organelle; membrane; plasma membrane
Molecular Function:  2-acylglycerol O-acyltransferase activity; diacylglycerol binding; diacylglycerol O-acyltransferase activity; fatty acid binding; O-acyltransferase activity; retinol O-fatty-acyltransferase activity; transferase activity; transferase activity, transferring acyl groups
Biological Process:  diacylglycerol metabolic process; fatty acid homeostasis; glycerolipid metabolic process; insulin secretion; ketone body metabolic process; lipid storage; long-chain fatty-acyl-CoA metabolic process; positive regulation of fatty acid oxidation; positive regulation of hepatic stellate cell activation; positive regulation of triglyceride biosynthetic process; regulation of eating behavior; regulation of intestinal lipid absorption; regulation of vitamin A metabolic process; triglyceride biosynthetic process; very-low-density lipoprotein particle assembly
Reference #:  Q9Z2A7 (UniProtKB)
Alt. Names/Synonyms: Acyl-CoA retinol O-fatty-acyltransferase; ARAT; C75990; D15Ertd23; D15Ertd23e; Dgat; Dgat1; diacylglycerol acyltransferase 1; Diacylglycerol O-acyltransferase 1; Diglyceride acyltransferase; Retinol O-fatty-acyltransferase
Gene Symbols: Dgat1
Molecular weight: 56,790 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene