TGFBR3 Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 5|5 E5
Cellular Component:  cell surface; cytoplasm; endoplasmic reticulum; external side of plasma membrane; extracellular matrix; extracellular region; extracellular space; inhibin-betaglycan-ActRII complex; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; receptor complex
Molecular Function:  activin binding; coreceptor activity; fibroblast growth factor binding; glycosaminoglycan binding; heparin binding; PDZ domain binding; protein binding; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type III; transforming growth factor beta receptor binding; transforming growth factor beta-activated receptor activity; type II transforming growth factor beta receptor binding
Biological Process:  blastocyst development; blood vessel development; blood vessel remodeling; BMP signaling pathway; cardiac epithelial to mesenchymal transition; cardiac muscle cell proliferation; collagen metabolic process; coronary vasculature development; coronary vasculature morphogenesis; definitive erythrocyte differentiation; definitive hemopoiesis; epicardial cell to mesenchymal cell transition; epicardium-derived cardiac fibroblast cell development; epithelial to mesenchymal transition; heart trabecula formation; heart trabecula morphogenesis; immune response; in utero embryonic development; intracellular signal transduction; liver development; muscular septum morphogenesis; negative regulation of apoptotic process involved in morphogenesis; negative regulation of cellular component movement; negative regulation of epithelial cell migration; negative regulation of epithelial cell proliferation; negative regulation of epithelial to mesenchymal transition; negative regulation of gene expression; negative regulation of transforming growth factor beta receptor signaling pathway; osteoblast differentiation; outflow tract morphogenesis; pathway-restricted SMAD protein phosphorylation; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation; positive regulation of NF-kappaB transcription factor activity; positive regulation of transforming growth factor beta receptor signaling pathway; protein-containing complex assembly; regulation of blood vessel size; regulation of protein binding; response to follicle-stimulating hormone; response to luteinizing hormone; response to prostaglandin E; roof of mouth development; secondary palate development; transforming growth factor beta receptor complex assembly; transforming growth factor beta receptor signaling pathway; vasculogenesis; vasculogenesis involved in coronary vascular morphogenesis; ventricular cardiac muscle tissue morphogenesis; ventricular compact myocardium morphogenesis; ventricular septum morphogenesis; visceral serous pericardium development
Reference #:  O88393 (UniProtKB)
Alt. Names/Synonyms: 1110036H20Rik; AU015626; AW215636; betagl; Betaglycan; TBRIII; TGBR3; TGF-beta receptor type 3; TGF-beta receptor type III; Tgfbr3; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3; transforming growth factor, beta receptor III
Gene Symbols: Tgfbr3
Molecular weight: 93,829 Da
Basal Isoelectric point: 5.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TGFBR3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene