TGFBR3 Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component:  cell surface; cytoplasm; external side of plasma membrane; extracellular matrix; extracellular space; inhibin-betaglycan-ActRII complex; integral component of plasma membrane; receptor complex
Molecular Function:  activin binding; coreceptor activity; fibroblast growth factor binding; glycosaminoglycan binding; heparin binding; PDZ domain binding; protein binding; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type III; transforming growth factor beta receptor binding; transforming growth factor beta-activated receptor activity; type II transforming growth factor beta receptor binding
Biological Process:  animal organ regeneration; BMP signaling pathway; cardiac epithelial to mesenchymal transition; cardiac muscle cell proliferation; cell migration; definitive erythrocyte differentiation; definitive hemopoiesis; epicardium-derived cardiac fibroblast cell development; epithelial to mesenchymal transition; heart morphogenesis; heart trabecula formation; heart trabecula morphogenesis; immune response; intracellular signal transduction; liver development; muscular septum morphogenesis; negative regulation of cellular component movement; negative regulation of epithelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; outflow tract morphogenesis; pathway-restricted SMAD protein phosphorylation; positive regulation of cardiac muscle cell proliferation; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein binding; response to follicle-stimulating hormone; response to hypoxia; response to luteinizing hormone; response to prostaglandin E; secondary palate development; transforming growth factor beta receptor complex assembly; transforming growth factor beta receptor signaling pathway; vasculogenesis involved in coronary vascular morphogenesis; ventricular cardiac muscle tissue morphogenesis; ventricular compact myocardium morphogenesis; ventricular septum morphogenesis
Reference #:  Q03167 (UniProtKB)
Alt. Names/Synonyms: Betaglycan; betaglycan proteoglycan; BGCAN; TGBR3; TGF-beta receptor type 3; TGF-beta receptor type III; TGFBR3; TGFR-3; Transforming growth factor beta receptor III; Transforming growth factor beta receptor type 3; transforming growth factor, beta receptor III
Gene Symbols: TGFBR3
Molecular weight: 93,499 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TGFBR3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein