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CYP2E1
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.14.13.n7; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 |
| Chromosomal Location of human Ortholog: 10q26.3 |
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Cellular Component:
cytoplasm; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; mitochondrial inner membrane
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Molecular Function:
4-nitrophenol 2-monooxygenase activity; arachidonic acid epoxygenase activity; aromatase activity; enzyme binding; heme binding; Hsp70 protein binding; Hsp90 protein binding; iron ion binding; long-chain fatty acid omega-1 hydroxylase activity; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; oxygen binding
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Biological Process:
4-nitrophenol metabolic process; benzene metabolic process; carbon tetrachloride metabolic process; epoxygenase P450 pathway; halogenated hydrocarbon metabolic process; heterocycle metabolic process; lipid hydroxylation; long-chain fatty acid biosynthetic process; long-chain fatty acid metabolic process; monoterpenoid metabolic process; response to bacterium; steroid metabolic process; xenobiotic metabolic process
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Reference #:
P05181
(UniProtKB)
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Alt. Names/Synonyms: 4-nitrophenol 2-hydroxylase; CP2E1; CPE1; CYP2E; CYP2E1; CYPIIE1; Cytochrome P450 2E1; cytochrome P450 family 2 subfamily E member 1; cytochrome P450, family 2, subfamily E, polypeptide 1; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1; Cytochrome P450-J; flavoprotein-linked monooxygenase; microsomal monooxygenase; P450-J; P450C2E; xenobiotic monooxygenase
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Gene Symbols: CYP2E1
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Molecular weight:
56,849 Da
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Basal Isoelectric point:
8.28
Predict pI for various phosphorylation states
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