CYP2E1 A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.13.n7; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 1q41
Cellular Component:  cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi membrane; intracellular membrane-bounded organelle; intrinsic component of endoplasmic reticulum membrane; mitochondrial inner membrane; mitochondrion
Molecular Function:  arachidonic acid epoxygenase activity; enzyme binding; FMN binding; heme binding; Hsp70 protein binding; Hsp90 protein binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; steroid hydroxylase activity
Biological Process:  drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; heterocycle metabolic process; monoterpenoid metabolic process; organic acid metabolic process; oxidation-reduction process; response to bacterium; response to drug; response to ethanol; response to organonitrogen compound; response to ozone; steroid metabolic process; triglyceride metabolic process; xenobiotic metabolic process
Reference #:  P05182 (UniProtKB)
Alt. Names/Synonyms: 4-nitrophenol 2-hydroxylase; Cyp2e; Cyp2e-1; Cyp2e1; CYPIIE1; Cytochrome P450 2E1; cytochrome P450 subfamily 2e1 (ethanol-inducible); cytochrome P450, family 2, subfamily e, polypeptide 1; cytochrome P450, subfamily 2E, polypeptide 1; Cytochrome P450-J; Cytochrome P450RLM6; P450-J; P450RLM6
Gene Symbols: Cyp2e1
Molecular weight: 56,627 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene