ESYT2 Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex. Belongs to the extended synaptotagmin family. Widely expressed with high level in cerebellum. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 12 F2|12 62.65 cM
Cellular Component:  endoplasmic reticulum; extrinsic component of cytoplasmic side of plasma membrane; integral component of membrane; integral component of plasma membrane; intrinsic component of endoplasmic reticulum membrane; membrane; organelle membrane contact site; plasma membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; identical protein binding; lipid binding; metal ion binding; phosphatidylcholine binding; phosphatidylethanolamine binding; phosphatidylinositol binding
Biological Process:  endocytosis; endoplasmic reticulum-plasma membrane tethering; lipid transport
Reference #:  Q3TZZ7 (UniProtKB)
Alt. Names/Synonyms: 2410017M09Rik; 4921504I16Rik; chr2 synaptotagmin; CHR2SYT; D12Ertd551; D12Ertd551e; E-Syt2; Esyt2; Extended synaptotagmin-2; extended synaptotagmin-like protein 2; Fam62; Fam62b; family with sequence similarity 62 (C2 domain containing), member B; family with sequence similarity 62, member B; KIAA1228
Gene Symbols: Esyt2
Molecular weight: 94,139 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene