|
IEX-1
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Belongs to the IER3 family. Note: This description may include information from UniProtKB.
|
| Protein type: Apoptosis; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 6p21.33 |
|
Cellular Component:
cytosol; membrane; mitochondrion; nucleus
|
|
Molecular Function:
protein binding
|
|
Biological Process:
anatomical structure morphogenesis; apoptotic process; DNA damage response; glycolytic process; intrinsic apoptotic signaling pathway in response to DNA damage; mitotic G2 DNA damage checkpoint signaling; negative regulation of apoptotic process; negative regulation of glycolytic process; negative regulation of inflammatory response; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; negative regulation of systemic arterial blood pressure; positive regulation of protein catabolic process; regulation of DNA repair; regulation of nucleocytoplasmic transport; regulation of reactive oxygen species metabolic process; response to protozoan
|
|
Reference #:
P46695
(UniProtKB)
|
|
Alt. Names/Synonyms: anti-death protein; DIF-2; DIF2; Differentiation-dependent gene 2 protein; expressed in pancreatic carcinoma; GLY96; gly96, mouse, homolog of; IER3; IEX-1; IEX-1L; IEX1; Immediate early protein GLY96; immediate early response 3; Immediate early response 3 protein; immediately early gene X-1; PACAP-responsive gene 1 protein; PRG1; Protein DIF-2; Protein PRG1; Radiation-inducible immediate-early gene IEX-1
|
|
Gene Symbols: IER3
|
|
Molecular weight:
16,903 Da
|
|
Basal Isoelectric point:
8.61
Predict pI for various phosphorylation states
|
