HOXA10 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'. Belongs to the Abd-B homeobox family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7p15.2
Cellular Component:  cytoplasm; nucleus; transcription factor complex
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  anterior/posterior pattern specification; embryonic limb morphogenesis; male gonad development; multicellular organism development; positive regulation of transcription by RNA polymerase II; proximal/distal pattern formation; single fertilization; skeletal system development; spermatogenesis; uterus development
Reference #:  P31260 (UniProtKB)
Alt. Names/Synonyms: homeo box A10; homeobox A10; homeobox protein 1H; Homeobox protein Hox-1.8; Homeobox protein Hox-1H; Homeobox protein Hox-A10; homeobox protein HOXA10; HOX1; HOX1.8; HOX1H; HOXA10; HXA10; MGC12859; PL
Gene Symbols: HOXA10
Molecular weight: 42,414 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB