NFH Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 14q21
Cellular Component:  axon; cytoplasm; cytoskeleton; intermediate filament; neurofibrillary tangle; neurofilament; nucleus; perikaryon; postsynaptic density; postsynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse
Molecular Function:  protein binding, bridging; protein heterodimerization activity; protein kinase binding; structural constituent of cytoskeleton; structural constituent of postsynaptic intermediate filament cytoskeleton; structural molecule activity; toxic substance binding
Biological Process:  axon development; axon regeneration; brain development; cellular response to estradiol stimulus; cellular response to leukemia inhibitory factor; cellular response to oxidative stress; cerebral cortex development; hippocampus development; intermediate filament bundle assembly; intermediate filament cytoskeleton organization; microtubule cytoskeleton organization; neurofilament bundle assembly; neurofilament cytoskeleton organization; neuron projection development; ovarian follicle atresia; peripheral nervous system neuron axonogenesis; regulation of organelle transport along microtubule; response to acrylamide; response to cocaine; response to sodium arsenite; spinal cord development
Reference #:  P16884 (UniProtKB)
Alt. Names/Synonyms: 200 kDa neurofilament protein; Nefh; Neurofilament heavy polypeptide; Neurofilament triplet H protein; neurofilament, heavy polypeptide; NF-H; Nfh
Gene Symbols: Nefh
Molecular weight: 115,378 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene