NFH
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. Belongs to the intermediate filament family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cytoskeletal |
Chromosomal Location of rat Ortholog: 14q21 |
Cellular Component:
apical dendrite; axon; basal proximal dendrite; cytoplasm; cytoskeleton; intermediate filament; neurofibrillary tangle; neurofilament; neuronal cell body; perikaryon; postsynapse; postsynaptic density; postsynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse
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Molecular Function:
protein kinase binding; protein-containing complex binding; protein-macromolecule adaptor activity; structural constituent of cytoskeleton; structural constituent of postsynaptic intermediate filament cytoskeleton; toxic substance binding
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Biological Process:
axon development; axon regeneration; cellular response to estradiol stimulus; cellular response to hydroperoxide; cellular response to leukemia inhibitory factor; cellular response to oxidative stress; cerebral cortex development; hippocampus development; intermediate filament bundle assembly; intermediate filament cytoskeleton organization; microtubule cytoskeleton organization; neurofilament bundle assembly; neurofilament cytoskeleton organization; neuron projection development; ovarian follicle atresia; peripheral nervous system neuron axonogenesis; postsynaptic intermediate filament cytoskeleton organization; postsynaptic modulation of chemical synaptic transmission; regulation of organelle transport along microtubule; response to acrylamide; response to cocaine; response to sodium arsenite; spinal cord development
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Reference #:
P16884
(UniProtKB)
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Alt. Names/Synonyms: 200 kDa neurofilament protein; Nefh; Neurofilament heavy polypeptide; Neurofilament triplet H protein; neurofilament, heavy polypeptide; NF-H; Nfh
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Gene Symbols: Nefh
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Molecular weight:
115,378 Da
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Basal Isoelectric point:
5.74
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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