NKCC1 Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume. Belongs to the SLC12A transporter family. Expressed in many tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 5q23.3
Cellular Component:  integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  ammonium transmembrane transporter activity; protein binding; protein kinase binding
Biological Process:  aging; ammonium transmembrane transport; ammonium transport; cellular response to chemokine; gamma-aminobutyric acid signaling pathway; hyperosmotic response; ion transport; positive regulation of cell volume; T cell chemotaxis; transepithelial ammonium transport; transepithelial chloride transport
Reference #:  P55011 (UniProtKB)
Alt. Names/Synonyms: Basolateral Na-K-Cl symporter; BSC; BSC2; Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; MGC104233; NKCC1; S12A2; SLC12A2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Solute carrier family 12 member 2
Gene Symbols: SLC12A2
Molecular weight: 131,447 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NKCC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene