RARG iso2 Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. Belongs to the nuclear hormone receptor family. NR1 subfamily. Expressed in aortic endothelial cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  integral component of membrane; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; retinoid X receptor binding; steroid hormone receptor activity; zinc ion binding
Biological Process:  anterior/posterior pattern specification; canonical Wnt signaling pathway; cellular response to leukemia inhibitory factor; embryonic camera-type eye development; embryonic eye morphogenesis; embryonic hindlimb morphogenesis; face development; glandular epithelial cell development; growth plate cartilage chondrocyte growth; Harderian gland development; multicellular organism growth; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of transcription by RNA polymerase II; neural tube closure; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; prostate gland epithelium morphogenesis; regulation of cell size; regulation of myelination; regulation of myeloid cell differentiation; response to retinoic acid; retinoic acid receptor signaling pathway; steroid hormone mediated signaling pathway; trachea cartilage development; transcription initiation from RNA polymerase II promoter
Reference #:  P13631-2 (UniProtKB)
Alt. Names/Synonyms: NR1B3; Nuclear receptor subfamily 1 group B member 3; RAR-gamma; RARC; RARG; RARG iso2; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; Retinoic acid receptor gamma; retinoic acid receptor, gamma
Gene Symbols: RARG
Molecular weight: 49,308 Da
Basal Isoelectric point: 7.42  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
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RARG iso2

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  RCSB PDB  |  Phospho3D  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein