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RARG iso2
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. Belongs to the nuclear hormone receptor family. NR1 subfamily. Expressed in aortic endothelial cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor |
| Chromosomal Location of human Ortholog: 12q13.13 |
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Cellular Component:
chromatin; cytoplasm; membrane; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
chromatin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; nuclear retinoid X receptor binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; zinc ion binding
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Biological Process:
anterior/posterior pattern specification; apoptotic process; canonical Wnt signaling pathway; cell differentiation; cellular response to leukemia inhibitory factor; cellular response to retinoic acid; embryonic camera-type eye development; embryonic eye morphogenesis; embryonic hindlimb morphogenesis; face development; glandular epithelial cell development; growth plate cartilage chondrocyte growth; Harderian gland development; hormone-mediated signaling pathway; multicellular organism growth; negative regulation of cell population proliferation; negative regulation of chondrocyte differentiation; negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; neural tube closure; positive regulation of apoptotic process; positive regulation of cell population proliferation; positive regulation of gene expression; positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; prostate gland epithelium morphogenesis; regulation of cell size; regulation of myelination; regulation of myeloid cell differentiation; response to retinoic acid; retinoic acid receptor signaling pathway; stem cell proliferation; trachea cartilage development
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Reference #:
P13631-2
(UniProtKB)
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Alt. Names/Synonyms: NR1B3; Nuclear receptor subfamily 1 group B member 3; RAR-gamma; RARC; RARG; RARG iso2; retinoic acid nuclear receptor gamma variant 1; retinoic acid nuclear receptor gamma variant 2; Retinoic acid receptor gamma; retinoic acid receptor, gamma
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Gene Symbols: RARG
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Molecular weight:
49,308 Da
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Basal Isoelectric point:
7.42
Predict pI for various phosphorylation states
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CST Pathways:
Wnt/ß-Catenin Signaling
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