RARG iso2 Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. Belongs to the nuclear hormone receptor family. NR1 subfamily. Expressed in aortic endothelial cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 15 F3|15 57.4 cM
Cellular Component:  nucleoplasm; nucleus; RNA polymerase II transcription factor complex; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; nuclear receptor activity; nuclear receptor transcription coactivator activity; protein binding; retinoid X receptor binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor activity; steroid hormone receptor activity; transcription factor binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  anterior/posterior pattern specification; bone development; bone morphogenesis; camera-type eye development; cell differentiation; cellular response to leukemia inhibitory factor; cellular response to retinoic acid; chondrocyte development; embryonic camera-type eye development; embryonic eye morphogenesis; embryonic hindlimb morphogenesis; epithelium development; face development; gland development; glandular epithelial cell development; growth plate cartilage chondrocyte growth; growth plate cartilage development; Harderian gland development; hormone-mediated signaling pathway; limb development; multicellular organism development; multicellular organism growth; negative regulation of apoptotic process; negative regulation of cartilage development; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of transcription by RNA polymerase II; neural tube closure; positive regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of programmed cell death; positive regulation of transcription by RNA polymerase II; prostate gland epithelium morphogenesis; regulation of gene expression; regulation of myelination; regulation of myeloid cell differentiation; regulation of transcription, DNA-templated; reproductive structure development; response to lipid; response to retinoic acid; retina development in camera-type eye; retinal pigment epithelium development; retinoic acid receptor signaling pathway; trachea cartilage development
Reference #:  P18911-2 (UniProtKB)
Alt. Names/Synonyms: AI385767; MGC11555; MGC18523; Nr1b3; Nuclear receptor subfamily 1 group B member 3; RAR gamma 2; RAR-gamma; RARD; Rarg; RARgamma2; Retinoic acid receptor gamma; retinoic acid receptor, gamma
Gene Symbols: Rarg
Molecular weight: 49,849 Da
Basal Isoelectric point: 7.79  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Select Structure to View Below

RARG iso2

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA