ATP6V0A2 Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Belongs to the V-ATPase 116 kDa subunit family. Note: This description may include information from UniProtKB.
Protein type: Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Transporter, iron
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  acrosomal vesicle; endosome; integral component of membrane; intracellular organelle; membrane; perinuclear region of cytoplasm; plasma membrane; proton-transporting V-type ATPase, V0 domain; vacuolar proton-transporting V-type ATPase complex; vacuolar proton-transporting V-type ATPase, V0 domain
Molecular Function:  ATPase binding; protein binding; proton transmembrane transporter activity; proton-transporting ATPase activity, rotational mechanism
Biological Process:  ATP hydrolysis coupled proton transport; cellular iron ion homeostasis; cellular response to increased oxygen levels; ion transport; vacuolar acidification
Reference #:  P15920 (UniProtKB)
Alt. Names/Synonyms: 8430408C20Rik; AI385560; ATP6a2; Atp6n1b; Atp6n1d; Atp6n2; Atp6v0a2; ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD); ATPase, H+ transporting, lysosomal V0 subunit a; ATPase, H+ transporting, lysosomal V0 subunit A2; AW489264; C76904; Immune suppressor factor J6B7; ISF; Lysosomal H(+)-transporting ATPase V0 subunit a2; MGC124341; MGC124342; ShIF; Stv1; T-cell expressing clone j6; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa; V-ATPase 116 kDa isoform a2; V-ATPase a2; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a isoform 2; vacuolar proton translocating ATPase 116 kDa subunit a; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2; VPP2
Gene Symbols: Atp6v0a2
Molecular weight: 98,145 Da
Basal Isoelectric point: 6.2  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene