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PKACG
Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; EC 2.7.11.11; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of Human Ortholog: 9q21.11 |
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Cellular Component:
ciliary base; cytosol; intercellular bridge; nucleoplasm
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Molecular Function:
ATP binding; cAMP-dependent protein kinase activity
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Biological Process:
activation of protein kinase A activity; blood coagulation; cellular response to glucagon stimulus; high-density lipoprotein particle assembly; male gonad development; protein phosphorylation; renal water homeostasis; spermatogenesis; stimulatory C-type lectin receptor signaling pathway
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Disease: Mental Retardation, Autosomal Dominant 31
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Reference #:
P22612
(UniProtKB)
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Alt. Names/Synonyms: BDPLT19; cAMP-dependent protein kinase catalytic subunit gamma; KAPCG; KAPG; PKA C-gamma; PKACg; PRKACG; protein kinase cAMP-activated catalytic subunit gamma; protein kinase, cAMP-dependent, catalytic, gamma; protein kinase, cAMP-dependent, gamma catalytic subunit; serine(threonine) protein kinase
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Gene Symbols: PRKACG
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Molecular weight:
40,434 Da
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Basal Isoelectric point:
8.7
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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AMPK Signaling
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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Hedgehog Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Microtubule Dynamics
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Mitochondrial Control of Apoptosis
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NF-kB Signaling
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Parkinson's Disease
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